I am an infectious diseases and microbiology consultant working at Barts Health NHS Trust. This includes working several months per year at St Bartholomew's Hospital, centre for specialised cardiology and cardiac surgery, as well as haematology/oncology, complex intensive care and ECMO patients and complex respiratory conditions. Our relatively young OPAT service at St Bartholomew's cares mainly for patients with endovascular infections, including endocarditis. We aim to have an integrated, flexible, patient-centered service. These are complex patients at higher risk of relapse and failure, and specific OPAT arrangements need to be considered if you are including them into your cohort. We will walk you through our experience so far, the pros and the cons. Is your service ready to accept these patients? Are you ready? Are your patients ready?